Fertility Consultation with a Reproductive Endocrinologist


A repro­duc­tive endocri­nol­o­gist is a spe­cial­ist trained in help­ing women / cou­ple get preg­nant. Care­ful prepa­ra­tion for fer­til­ity con­sul­ta­tion and ade­quate time devoted to the encounter itself can help iden­ti­fy­ing infer­til­ity fac­tors and point­ing to the most cost-efficient fer­til­ity treatment.

Who should con­sider fer­til­ity consultation?

1. Women or cou­ple not able to con­ceive after two years (female age <35 years), one year (female age >35 years) or 6 months (female age >40 years) espe­cially after repeated unsuc­cess­ful attempts at timed inter­course or sim­ple treat­ment (e.g clomid)

2. Women with known fer­til­ity fac­tor (no ovu­la­tion, endometrio­sis or tubal dis­ease / pelvic scar­ring, fibroids..)

3. Men with known fer­til­ity fac­tor (decrease count, motil­ity or mor­phol­ogy of sperm, dif­fi­culty with ejac­u­la­tion or erection)

4. Women or men who are at risk for reduced fer­til­ity due to dis­ease or dis­ease treat­ment (e.g. can­cer, can­cer treat­ment, chemother­apy, lupus, prior surgery, irreg­u­lar menses or absence of menstruation)

5. Recur­rent preg­nancy loss in the first or sec­ond trimester of pregnancy

6. Women or men known to be car­ri­ers of genetic dis­ease, con­ceived in a baby affected with a genetic dis­ease or with fam­ily his­tory of genetic prob­lems (e.g. chro­mo­so­mal abnor­mal­ity, sickle cell dis­ease, BRCA carrier..)

7. Other indi­ca­tions: same sex cou­ple, indi­vid­u­als desir­ing preg­nancy through donor sperm or donor oocytes, women desir­ing fer­til­ity exten­sion through social egg freezing

Prepa­ra­tion before fer­til­ity consultation

Col­lect prior med­ical doc­u­ments 1. Sperm analy­sis 2. Hys­teros­alp­in­gogram (HSG) report and films if avail­able 3. Lab tests 4. Genetic con­sul­ta­tions if any 4. Med­ical reports from your physi­cian about any sig­nif­i­cant dis­ease 5. Oper­a­tive reports of any abdom­i­nal or pelvic surgery. Allot 1.5 hours for the con­sul­ta­tion and write down any ques­tions that come to your mind.

Dur­ing Consultation

Struc­tured con­sul­ta­tion with  a repro­duc­tive endocri­nol­o­gist con­sumes approx­i­mately 60 to 90 min­utes. Com­po­nents of encounter include

1. His­tory: to review infor­ma­tion related to ovar­ian, tubal and male fac­tors of infer­til­ity as well as med­ical, sur­gi­cal and per­sonal his­to­ries. Detailed fam­ily and genetic his­tory is essen­tial to iden­tify and pos­si­bly test for risk fac­tors of genetic dis­ease in the newborn.

2. Exam­i­na­tion includ­ing gen­eral, abdom­i­nal and pelvic examination

3. pelvic ultra­sound aim­ing at detect­ing abnor­mal­i­ties in the uterus, ovaries and the pelvis. Ultra­sound is an excel­lent tool to esti­mate ovar­ian reserve-antral fol­li­cle count.

4. Explain­ing the required tests needed to inves­ti­gate ovar­ian reserve, male and tubal fac­tors as well as pre­na­tal tests required of any woman attempt­ing to conceive.

5. Out­lin­ing a pro­vi­sional plan for inves­ti­ga­tion and treat­ment of infertility.

All the required tests can be final­ized within 2 to 3 weeks, enabling the per­son or cou­ple to make informed deci­sion about the next step in fer­til­ity treatment

 After Consultation

Before mak­ing any treat­ment deci­sions con­cen­trate on com­plet­ing the required inves­ti­ga­tion includ­ing sperm analy­sis, test for tubal patency (HSG) and tests for ovar­ian reserve. Pre­na­tal tests before attempt­ing to con­ceive includ­ing repro­duc­tive hor­mone assay, infec­tious dis­ease pro­file and genetic screen­ing tests should also be obtained.

A sec­ond visit or phone call with your repro­duc­tive endocri­nol­o­gists out­lin­ing the results of fer­til­ity tests is highly advis­able. Based on the­ses tests, treat­ment plans are finalized.

Five points to con­sider before start­ing treatment

1. Time com­mit­ment: Fer­til­ity treat­ment may require mul­ti­ple vis­its over sev­eral months. Its impor­tant that vis­its are tai­lored around your sched­ule with min­i­mal time off work.

2. Cost is also an impor­tant con­sid­er­a­tion as well as resources avail­able to help you.

3. Poten­tial unde­sired out­come espe­cially mul­ti­ple preg­nancy. For exam­ple women desir­ing only a sin­gle­ton preg­nancy should lean towards IVF with sin­gle embryo trans­fer rather ovu­la­tion induc­tion with gonadotropin injections.

4. Risk of preg­nancy in older women and women with med­ical disorders

5. Is surgery required before fer­til­ity enhanc­ing treat­ment e.g. removal of polyps or fibroids

If you decide to pur­sue treat­ment you need to be advised of the sched­ule of treat­ment cycle, type and self admin­is­tra­tion of medication.

After achiev­ing pregnancy

You should undergo all rec­quied preg­nancy screen­ing includ­ing screen­ing for abnor­mal chro­mo­somes in the fetus, amnio­cen­te­sis of chori­onic vil­lous sampling-CVS even if preim­plan­ta­tion genetic diagnosis-PGD was done on embryos as well as con­sult with high risk obste­tri­cian if needed.


What Does Borderline Ovarian Tumor Mean to Your Fertility?


Tweet Fer­til­ity in women diag­nosed with bor­der­line ovar­ian tumors can be reduced or lost due to sur­gi­cal treat­ment. Coun­sel­ing regard­ing fer­til­ity preser­va­tion shortly after diag­no­sis can increase the chance of preg­nancy fol­low­ing treat­ment. Borderline-low malig­nant poten­tial ovar­ian tumors The cells in bor­der­line tumors, pro­lif­er­ate more than benign ovar­ian cysts but less than frank malig­nant ovar­ian


Ovarian Reserve Revisited-Do You Have Enough Good Eggs?


Tweet Try­ing to con­ceive over age 35 is gen­er­ally not easy I know because I tried for years to have a baby with­out suc­cess.  While there are many fac­tors which impact con­cep­tion, one of the first con­cerns for women over 35 is if they have enough healthy eggs to get preg­nant.  Research has shown that women


Fertility and Fertility Preservation-Beware of What You Read


Tweet Fer­til­ity treat­ment espe­cially assisted repro­duc­tive technology-IVF enabled many women to achieve preg­nancy even those with the most dif­fi­cult cases of infer­til­ity. Advances include ICSI-injection of a sin­gle sperm into an egg ‚  PGD-biopsy of embryos and polar bod­ies for genetic diag­no­sis, of spe­cific genetic dis­eases, pro­longed cul­ture of embryos to blas­to­cyst stage-day 5 to


Endometriosis and Future Fertility


Tweet Endometrio­sis can have pro­found effects on woman’s fer­til­ity and the abil­ity to con­ceive in the future, either by virtue of the dis­ease itself or its treat­ment. Endometrio­sis means that the tis­sue that lines the uterus is found in other areas, most notably the ovaries and the lin­ing of the pelvis, fre­quently caus­ing pelvic pain


Fertility Preservation via In Vitro Maturation


Tweet In vitro mat­u­ra­tion of human oocytes can be used for fer­til­ity preser­va­tion. In vitro maturation-IVM indi­cates that eggs are retrieved with­out stim­u­la­tion or after a short period-about 3 days-of treat­ment with fer­til­ity med­ica­tion. Oocytes are then either 1. Frozen as imma­ture eggs, 2. Matured in the lab for 24 to 30 hours and then


Fertility in Women Diagnosed with Chronic Myeloid Leukemia


Women and men diag­nosed with chronic myeloid leukemia should con­sider fer­til­ity issues due to the pos­si­ble effects of treat­ment on future fer­til­ity and pos­si­ble require­ment of stem cell trans­plan­ta­tion in the future. Women inter­ested in achiev­ing a preg­nancy should con­sult their oncol­o­gist and a repro­duc­tive endocri­nol­o­gist with exper­tise in fer­til­ity preservation.


Fertility in Men Diagnosed with Cancer


Tweet Who needs to con­sider preser­va­tion of Fer­til­ity? a. The Amer­i­can Can­cer Soci­ety esti­mates that 760,000 men will be diag­nosed with can­cer in 2009. Can­cer itself (before treat­ment) is some­times asso­ci­ated with less sperm pro­duc­tion in men. This is spe­cially the case in Hodgkin’s lym­phoma, tes­tic­u­lar can­cer, prostate can­cer, leukemias and colon can­cer. The most


Fertility Treatment in Women Carrying BRCA Mutations


Young women car­ry­ing BRCA muta­tion fre­quently con­sult with repro­duc­tive endocri­nol­o­gists for fer­til­ity treat­ment or preser­va­tion. Its unlikely that fer­til­ity or fer­til­ity treat­ment will increase the risk for breast can­cer in women with BRCA muta­tions. It appears that a BRCA muta­tion is not asso­ci­ated with infer­til­ity or low response to fer­til­ity medication.


Melanoma-What Every Woman Need to Know about Fertility and Pregnancy


Melanoma is one of the most com­mon can­cers in young women. Women diag­nosed with melanoma and melanoma sur­vivors may require coun­sel­ing on fer­til­ity preser­va­tion, fer­til­ity treat­ment as well as the safety of preg­nancy. Use of fer­til­ity med­ica­tions does not appear to increase the risk for melanoma and preg­nancy does not appear to pose increased risk espe­cially in women with thin melanomas.


You are a breast cancer survivor, what next? Roadmap to pregnancy after treatment


Women treated for breast can­cer demon­strate vari­able ovar­ian reserve depend­ing on age and type and inten­sity of chemother­apy. Suc­cess of fer­til­ity treat­ment depends on ovar­ian func­tion. They require test­ing for ovar­ian func­tion and exten­sive coun­sel­ing by a repro­duc­tive endocri­nol­o­gist regard­ing the safety of ovar­ian stim­u­la­tion and IVF as well as preg­nancy. Options include inter­course, ovar­ian stim­u­la­tion and IUI, IVF, trans­fer of frozen embryos.


Thyroid Cancer and Future Fertility


Women treated with radioac­tive iodine for thy­roid can­cer may expe­ri­ence reduced ovar­ian reserve and infer­til­ity espe­cially in the later repro­duc­tive years. Some men also develop low sperm pro­duc­tion after radioio­dine treat­ment. Options for fer­til­ity preser­va­tion include sperm cry­op­reser­va­tion in men and egg or embryo freez­ing in women. Con­sul­ta­tion with a repro­duc­tive endocri­nol­o­gist may clar­ify the effects of radioio­dine on fer­til­ity and options for preser­va­tion of fertility.


How to Preserve Fertility after prostate cancer


Prostate can­cer is the most com­mon malig­nant tumor in men. Its increas­ingly diag­nosed in young men. Prostate can­cer treat­ment can lead to loss of fer­til­ity. Options for fer­til­ity preser­va­tion include sperm freez­ing and sperm har­vest from the testes-TESE


Ovarian cysts and Fertility-what women need to know


Surgery for ovar­ian cysts reduces ovar­ian reserve. Preser­va­tion of fer­til­ity in women desir­ing future preg­nancy is pos­si­ble through obser­va­tion, con­ser­v­a­tive surgery, egg freez­ing, embryo freez­ing or ovar­ian tis­sue freez­ing. Con­sul­ta­tion with a repro­duc­tive endocri­nol­o­gist allows test­ing for ovar­ian reserve before and after surgery and dis­cus­sion of fer­til­ity preser­va­tion plan.


Is it safe for women to get pregnant after breast cancer treatment


Women who got preg­nant fol­low­ing breast can­cer diag­no­sis and treat­ment had sig­nif­i­cantly bet­ter sur­vival com­pared to women who did not get pregnant


Mobile application and breast cancer


Soft­ware appli­ca­tions for breast can­cer diag­no­sis, risk, treat­ment and recur­rence are avail­able to help women track mul­ti­ple aspects of their disease.


Fertility preservation in uterine cancer and endometrial hyperplasia


Tweet The endometrium is the inner lin­ing of the uterus. Changes in the endometrium can take place with pro­longed expo­sure to estro­gen, unop­posed by prog­es­terone. This can take place in women who do not ovu­late reg­u­larly. Changes usu­ally start as exces­sive proliferation-cell divi­sion– and then may progress to can­cer. Endome­trial hyper­pla­sia and can­cer are prob­lems


Cancer in children and future reproduction


Tweet In 2010, approx­i­mately 10,500 boys and girls in the US and 160,000 world­wide are expected to be diag­nosed with can­cer before the age of 15. In addi­tion hun­dreds of thou­sands of ado­les­cents are treated for can­cer yearly between the ages of 15 to 19. The spe­cific type of can­cer varies with age and geo­graph­i­cal dis­tri­b­u­tion. 


Estrogen receptor negative breast cancer and future fertility


Tweet Breast can­cer is diag­nosed in 240,000 repro­duc­tive age women each year world­wide and approx­i­mately 25,000 in the US. Breast can­cer is usu­ally clas­si­fied into estro­gen recep­tor pos­i­tive or estro­gen recep­tor neg­a­tive depend­ing whether the cells express the pro­tein that ren­ders the cell respon­sive to estro­gen.  In 2010, The Amer­i­can soci­ety for Clin­i­cal Oncol­ogy and


Hodgkin Lymphoma and fertility in women and men


Tweet Lym­phoma is can­cer of lym­pho­cytes, the cells that are part of human immune sys­tem. The dis­ease was first described in 1832 and can start any­where lym­pho­cytes are found (lymph nodes, spleen, bone mar­row, or diges­tive tracts). Two types are rec­og­nized; Hodgkin lym­phoma (HL) and non-Hodgkin lym­phoma (NHL). The Amer­i­can Can­cer soci­ety esti­mates that approx­i­mately


More about chemotherapy for women


Tweet I hope you do not need to know about chemother­apy. If you stum­ble upon this word because you or loved ones need to be treated for can­cer or other con­di­tions, there is much more you need to know about chemother­apy than its just not a pleas­ant treat­ment. Chemother­apy is a group of med­ica­tion that


Ovarian reserve; what does it mean to you ?


Tweet I met this emi­nent repro­duc­tive endocri­nol­o­gist from Europe at a con­fer­ence and we were dis­cussing low egg reserve and he ver­bal­ized what repro­duc­tive endocri­nol­o­gists always knew but in a very clear state­ment ” you can­not cre­ate a repro­duc­tive poten­tial for a woman, a good repro­duc­tive endocri­nol­o­gist can take a woman and get her to


Egg freezing; ready for prime time?


Tweet Egg freez­ing is an advanced form of assisted repro­duc­tive tech­nol­ogy. It com­monly entails freez­ing of mature unfer­til­ized human egg. If the egg sur­vive thaw­ing, its then fer­til­ized with a sin­gle sperm by direct injec­tion (intra­cy­to­plas­mic sperm injec­tion or ICSI). In this post I dis­cuss the his­tory, biol­ogy and suc­cess of egg freez­ing. No opin­ions,


Fertility preservation versus fertility extension


Tweet Fer­til­ity preser­va­tion is defined as the appli­ca­tion of sur­gi­cal, med­ical, or lab­o­ra­tory pro­ce­dures to pre­serve the poten­tial for genetic par­ent­hood in adults or chil­dren at risk of steril­ity before the end of the nat­ural repro­duc­tive lifes­pan (R Gos­den 2009). Fer­til­ity exten­sion on the other hand is not a med­ical term found in sci­en­tific lit­er­a­ture.


BRCA mutations, breast cancer and fertility


Tweet Muta­tion in the breast can­cer sus­cep­ti­bil­ity genes (BRCA1 and 2) increases the life­time risk for early breast and ovar­ian can­cers. Women are com­monly approached by physi­cians to be tested (a blood test) if they fit cer­tain cri­te­ria that are asso­ci­ated with increased risk for find­ing these muta­tions. Actu­ally there are now two soft­ware pack­ages


Colon Cancer, true Stories


Tweet Anna is a 34 year old that was recently diag­nosed with col­orec­tal can­cer. Many pub­lic fig­ures devote their time and effort to pro­mote aware­ness of col­orec­tal can­cer. Colon can­cer in young women and men and its effect on future fer­til­ity com­monly pass unno­ticed. Anna’s oncol­o­gist told her that the treat­ment of her can­cer should


Breast cancer and Ovarian Stimulation: Safety & Other Considerations


Tweet Women diag­nosed with breast can­cer and desir­ing preser­va­tion of fer­til­ity via egg or embryo freez­ing require spe­cial con­sid­er­a­tion because a. its the most com­mon can­cer in women and b. its estro­gen sen­si­tive. Estro­gen increases five to ten folds dur­ing con­ven­tional ovar­ian stim­u­la­tion. Lim­it­ing estro­gen expo­sure dur­ing stim­u­la­tion appears to be an impor­tant safety con­sid­er­a­tion.


Psychological Support in Women Diagnosed with cancer:The Swiss Model


Tweet Young women and men diag­nosed with can­cer and inter­ested in learn­ing more about their options for future fam­ily build­ing require a great deal of sup­port. As they pro­ceed with these coura­geous steps, var­i­ous health care providers should rise to the occa­sion with can­did coun­sel­ing tai­lored to their med­ical and emo­tional needs. The tenets of


Lupus nephritis! What is that?


Tweet Sys­temic lupus ery­the­mato­sus (SLE) belongs to a group called auto-immune dis­eases. The immune cells lose their mem­ory and start attack­ing other body cells instead of offend­ers. In SLE, many types of cells are attacked by immune cells includ­ing kid­ney cells (lupus nephri­tis). It most com­monly takes place in young women. Dam­age to kid­ney cells has


Menses is not Fertility


Menses is not fer­til­ity. Expo­sure to chemother­apy for can­cer treat­ment is asso­ci­ated with accel­er­ated loss of eggs. Although some women may have enough fol­li­cles to pro­duce estro­gen and men­stru­ate, the num­ber remain­ing in the ovary is greatly reduced after chemother­apy (cyclophos­phamide). If you were diag­nosed with can­cer you are more likely to suc­ceed in con­ceiv­ing a child if you attempt to pre­serve your fer­til­ity prior to chemother­apy than if you present with infer­til­ity after chemotherapy.